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Patients with Hypertension Who Lose Substantial Amounts of Weight Can Positively Impact Risk Factors and Need for Medications

Grant L, Gotthelf L.
Obes 2007;15 suppl:A98.

Objectives:  Overweight is a known risk factor for hypertension and weight loss is recommended as the initial therapeutic task. The purpose of this study was to evaluate if hypertensive patients who participate in a structured, research-based behavioral program can positively impact their medical risk factors and need for blood pressure medications.

Subjects:  Patients who entered the HMR® Program for Weight ManagementTM with systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg and were not on blood pressure medications. Data were analyzed for those who completed a follow-up health risk appraisal from January, 2005, to April, 2007, and entered the maintenance program.

Programs:  HMR offers a range of weight-loss treatment options, including medically supervised low and very low-calorie diets, moderately restricted diets and phone-based programs as well as long-term maintenance. The program is based on measurable, evidence-based variables allowing for specific goals to be set and compliance to be tracked. All options for weight loss and maintenance focus on the same lifestyle changes: increased physical activity (> 2000 kcal/wk); use of meal replacements (> 35/wk in weight loss and 14/wk in maintenance); increased vegetable and fruit intake (> 35/wk) is included in some weight-loss options and in maintenance.

Results: 

Measure

No BP Medications 
at Follow-up

On BP Medications 
at Follow-up

Number of Patients

60

13

Start Weight

268 lbs.

233 lbs

Weight Loss

–54 lbs. (20.1%)

–4 lbs. 
(1.7%)

Total Cholesterol/HDL

–17.6%

–6.5%

Triglycerides

–30.9%

+8.0%

Systolic Blood Pressure

–24 mmHg

–7 mmHg

Diastolic Blood Pressure

–18 mmHg

–14 mmHg

Fasting Blood Glucose

–5.0%

+29.7%

Medical changes occurred in addition to substantial decreases and/or elimination of other medications

Conclusions:  Patients who lost substantial amounts of weight and made lifestyle changes in a structured weight management program were able to avoid the need for hypertensive medications. Weight loss and lifestyle changes should be the first therapeutic task for hypertensive patients.

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