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Patients with diabetes who lose greater amounts of weight have greater reductions in fasting lipids, hyperlipidemia medications and associated costs compared to those who lose modest amounts of weight.
Obes 2012:S170.Data from 139 patients with type 2 diabetes on diabetes medications were analyzed. At an average of 111 weeks follow-up, 23.3% of those who lost 5-10% of initial weight (average of 20 lbs) had discontinued hyperlipidemia medications. At an average of 90 weeks follow-up, 41% of those who lost ≥ 20% of initial weight (average of 81 lbs) had discontinued hyperlipidemia medications.
Patients with diabetes who lose greater amounts of weight have greater reductions in fasting blood glucose, diabetes medications and associated costs compared to those who lose modest amounts of weight.
Obes 2012:S170.Data from 139 patients with type 2 diabetes on diabetes medications were analyzed. At an average of 111 weeks follow-up, 19% of those who lost 5-10% of initial weight had discontinued insulin and 29.8% had discontinued oral medications. At an average of 90 weeks follow-up, 53.5% of those who lost ≥ 20% of initial weight had discontinued insulin and 57.7% had discontinued oral medications.
Greater weight loss maintenance in patients with diabetes impacts medication use.
Obes 2011;19 suppl 1:S97.Factors that differentiated patients with diabetes who were able to eliminate medications versus those who were not included greater weight loss maintenance (56 vs. 35 lbs) and greater physical activity. The no diabetes medication patients also eliminated more cholesterol (53% vs. 16%) and more blood pressure medications (48% vs. 13%) than patients who did not eliminate diabetes medications.
Weight loss impacts pre-diabetes in participants in an ongoing behavioral treatment program.
Obes 2010;18 suppl 2:S85.Compared with patients with fasting blood glucose > 100 mg/dL at follow-up, those with glucose < 100 mg/dL lost significantly more weight (56 vs. 30 lbs), had greater decreases in TC/HDL(14.8% vs. 10.6%) and triglycerides (26.3% vs. 5.3%). Those with lower glucose discontinued 26.4% of cholesterol and blood pressure medications (vs. 16.9%) and no patients went on diabetes medications at follow-up.
Patients with Pre-diabetes Who Lose Greater Amounts of Weight Have Greater Reductions in Medical Risk Factors and Medication Use
Obes 2009;17:suppl 2:S278Changes in medical risk factors and medication use were assessed in patients with pre-diabetes by weight change categories (> 100 lbs, 50-99 lbs, 1-49 lbs, weight gain). Although all weight loss categories had substantial health benefits, there was a dose-response relationship between weight loss and health changes with those losing the most weight having the greatest changes. The percent on diabetes medications at follow-up by weight loss category were: 0%, 1.8%, 6.3% and 10.5% respectively.
Patients with diabetes who lost > 20% of initial body weight (average of 89 lbs.) were 2-3 times more likely to come off insulin, oral diabetes, cholesterol and blood pressure medications compared to patients who lost 5-10% of initial weight.